LymphedemaV1, Main, Exploration, bibRecord, 00D581

Changes in circulating parasite antigen levels after treatment of bancroftian filariasis with diethylcarbamazine and ivermectin.

Identifieur interne : 00D581 ( Main/Exploration ); précédent : 00D580; suivant : 00D582

Changes in circulating parasite antigen levels after treatment of bancroftian filariasis with diethylcarbamazine and ivermectin.

Auteurs : G J Weil [États-Unis] ; P J Lammie ; F O Richards ; M L Eberhard

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 1991.

RBID : pubmed:1894943

Descripteurs français

KwdFr :
- Animaux, Antigènes d'helminthe (sang), Diéthylcarbamazine (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (usage thérapeutique), Microfilaria (), Wuchereria bancrofti (), Wuchereria bancrofti (immunologie).
MESH :
- immunologie : Filariose lymphatique, Wuchereria bancrofti.
- sang : Antigènes d'helminthe, Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Ivermectine.
- Animaux, Humains, Microfilaria, Wuchereria bancrofti.

English descriptors

KwdEn :
- Animals, Antigens, Helminth (blood), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Humans, Ivermectin (therapeutic use), Microfilariae (drug effects), Wuchereria bancrofti (drug effects), Wuchereria bancrofti (immunology).
MESH :
- chemical , blood : Antigens, Helminth.
- chemical , therapeutic use : Diethylcarbamazine, Ivermectin.
- blood : Elephantiasis, Filarial.
- drug effects : Microfilariae, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- Animals, Humans.

Abstract

This study assessed changes in circulating parasite antigen levels after diethylcarbamazine (DEC) and ivermectin treatment of bancroftian filariasis to determine effects of these drugs on adult Wuchereria bancrofti in vivo. Thirty adult Haitians with microfilaremia were treated with 1 mg of ivermectin to reduce counts of microfilariae. Later, subjects were treated with either one or two 200 micrograms/kg doses of ivermectin or with 12 daily 6 mg/kg doses of DEC. Macrofilaricidal activity of these drugs was indirectly monitored by measuring circulating W. bancrofti antigen by EIA. Antigen levels fell by 75% after DEC and by 34% after ivermectin. These results suggest that low-dose ivermectin treatment followed by a standard course of DEC is a more effective macrofilaricidal regimen for W. bancrofti than either of the multidose ivermectin regimens used in this study.

PubMed: 1894943

Affiliations:

Le document en format XML

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<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (immunology)</term>
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<term>Wuchereria bancrofti (immunology)</term>
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<term>Filariose lymphatique (sang)</term>
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<term>Ivermectine (usage thérapeutique)</term>
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<term>Wuchereria bancrofti ()</term>
<term>Wuchereria bancrofti (immunologie)</term>
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<front><div type="abstract" xml:lang="en">This study assessed changes in circulating parasite antigen levels after diethylcarbamazine (DEC) and ivermectin treatment of bancroftian filariasis to determine effects of these drugs on adult Wuchereria bancrofti in vivo. Thirty adult Haitians with microfilaremia were treated with 1 mg of ivermectin to reduce counts of microfilariae. Later, subjects were treated with either one or two 200 micrograms/kg doses of ivermectin or with 12 daily 6 mg/kg doses of DEC. Macrofilaricidal activity of these drugs was indirectly monitored by measuring circulating W. bancrofti antigen by EIA. Antigen levels fell by 75% after DEC and by 34% after ivermectin. These results suggest that low-dose ivermectin treatment followed by a standard course of DEC is a more effective macrofilaricidal regimen for W. bancrofti than either of the multidose ivermectin regimens used in this study.</div>
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Changes in circulating parasite antigen levels after treatment of bancroftian filariasis with diethylcarbamazine and ivermectin.

Changes in circulating parasite antigen levels after treatment of bancroftian filariasis with diethylcarbamazine and ivermectin.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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